A Picture Guide on How to Use the PANGEA-SMM Calculator

1. Enter your laboratory results and age.

To use PANGEA, you need three (3) numbers from your laboratory results.

Some tests might be called different names. Here are some examples:

1. M-spike = monoclonal protein = M-protein

2. Creatinine = Cr

3. Free light chain ratio = FLC ratio = involved over uninvolved ratio

4. Hemoglobin = Hgb

2. Enter your laboratory values.

Enter the numbers for each test result in the associated boxes on the left column.

Pay attention to units! If you are in the United States, PANGEA uses the most common units used in hospitals and clinics. Use Google or ask for help if you need to convert your results to the units listed on the Calculator.

3. (optional) Enter your bone marrow biopsy.

The PANGEA Calculator works whether you have had a bone marrow biopsy or not. Skip this step if you have not had a bone marrow biopsy done!

If you've had a bone marrow biopsy, enter the percent (%) of plasma cells (PCs) from your core sample. Ask your doctor if you are not sure what this number is!

4a. (optional) Enter your past results (1/2).

The PANGEA Calculator can analyze how your results change over time to better predict your progression risk. If you have only one (1) lab report, you can skip this step!

Start with hemoglobin: enter the date (Year–Month) of your most recent hemoglobin result and the corresponding hemoglobin value below. Then proceed to the next optional step (4b).

4b. (optional) Enter your past results (2/2).

After entering your latest hemoglobin value, navigate to the "Risk prediction with patient history" tab.

Enter the date, FLC ratio, M-spike, creatinine and hemoglobin from a previous lab report, and click the "Add Observation" button.

Repeat this process for as many lab reports as you have. If a parameter was not analyzed at a given time, you may leave the value blank before clicking "Add Observation."

When you have entered all your previous lab values, click "Update Prediction with Patient History."

5. Read your PANGEA results!

The PANGEA Calculator will automatically calculate your results based on what you have entered.

The PANGEA Calculator predicts your chance of progressing from SMM to multiple myeloma in the future.

Remember, the PANGEA Calculator tries its best but is not perfect. Ask your doctor to help you understand your results and what they mean for your clinical care!